Genentech, Glycart and Roche enter into collaboration agreement for potential cancer therapy
October 03, 2008 | by Roche
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October 03, 2008, Schlieren/Basel. Genentech, Inc. (NYSE: DNA), GlycArt, a company wholly-owned by Roche, and Roche (SWX: ROG) have entered into a collaboration agreement, including a licence from GlycArt to Genentech, for the joint development and commercialization of GlycArt’s GA101 molecule. The companies will be developing GA101, a humanized anti-CD20 monoclonal antibody engineered to increase both direct- and immune-mediated target cell death, for the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as non-Hodgkin’s lymphoma.
Pablo Umaña, Chief Scientific Officer and co-founder of GlycArt said: “With its unique mode of action, we believe GA101 has the potential to extend the therapeutic benefit over current standards of care, including treatment for patients who do not respond to current therapies.”
“This collaboration with GlycArt and Roche for the GA101 molecule complements our existing research program and our focus on innovative compounds, “said Hal Barron, M.D., Genentech Senior Vice President, development and chief medical officer. “We are pleased that through this program we may have the potential to offer a new option to treat patients with hematological malignancies.”
William M. Burns, CEO of Roche’s Pharmaceutical Division, commented “The exciting work in monoclonal antibody engineering carried out by our scientists at GlycArt is now moving through Roche Group companies to the next stage in developing clinically differentiated treatments.”
In association with this agreement, Genentech, Roche and GlycArt will share certain development costs and Genentech will record $105 million in research and development expense in its third quarter 2008 results. Genentech will receive commercialization rights in the United States.
GA101 is currently in Phase I/II clinical trials for CD20-positive B-cell malignancies, such as non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL). GlycArt and Roche plan to provide an update on phase I data for GA101 at the American Society of Hematology meeting in December 2008.
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Source: Roche, Press release